Upper Takutu-Upper Essequibo Region is a region of Guyana.
Boundaries: Natural Earth (naturalearthdata.com), public domain
Nothing has been written about Upper Takutu-Upper Essequibo Region here, and neither Wikipedia nor Wikivoyage has an article we could draw one from. If you know the place, that makes you a better source than anything we have. Tell us what is worth knowing and where you got it.
We show Lethem as the capital of Upper Takutu-Upper Essequibo Region. If that is wrong, tell us what it should be and where you read it.
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